Figure 2: Condition Evaluation and Decision-Making Algorithm illustrates the decision-making process.

For a given condition, if no test is available, it is not recommended for screening, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is less than 1,000 and the condition is not detected as part of a multiplex profile, it is not recommended for screening, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is less than 1,000 and the condition is detected as part of a multiplex profile, it is a secondary target, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is between 1,000 and 1,200 and the condition is part of a differential diagnosis for a core condition, it is a secondary target, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is between 1,000 and 1,200 and the condition is not part of a differential diagnosis for a core condition and is not detected as part of a multiplex profile, it is not recommended for screening, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is greater than 1,200 and treatment is neither available nor necessary but the condition is part of a differential diagnosis for a core condition, it is a secondary target, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is greater than 1,200 and treatment is neither available nor necessary and the condition is not part of a differential diagnosis for a core condition, it is not recommended for screening, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is greater than 1,200 and treatment is available and/or necessary, but the natural history is not well understood, it is a secondary target, but is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.

For a given condition, if a test is available and the survey score is greater than 1,200 and treatment is available and/or necessary, but the natural history is well understood, it is part of the core panel. If the patient is a carrier, the condition is also a secondary target, and is to be reconsidered if new screening methods or instruments or new knowledge of natural history are developed.