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Maternal and Child Health Pediatric Research Network Program. PROS (MCH PedsRN)

Project profile

Institution: American Academy of Pediatrics
Principal Investigator: Alexander Fiks
Project Number: U5DMC39344
Project Date: 09-01-2020

Age Group(s)

  • Perinatal/Infancy (0-12 months)
  • Toddlerhood (13-35 months)
  • Early Childhood (3-5 years)
  • Middle Childhood (6-11 years)
  • Adolescence (12-18 years)

Targeted/Underserved Population

  • African American
  • Asian/Pacific Islander
  • Hispanic/Latino
  • Native American/Alaskan Native
  • Immigrant
  • Rural


For 34 years the American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) national primary care practice-based research network (RN) has conducted groundbreaking stakeholder-informed research that: 1) builds the evidence-base for primary care; 2) informs clinical policy (including practice guidelines); and 3) provides new resources and tools for practices and families. Practice based research is needed to address the unmet needs of children across the life course the changing epidemiology of pediatric disease and the remaining gaps in the evidence base for primary care. The capacity for responsive practice-based research has heightened importance in a time of rapid change due to COVID-19.

Goals and objectives:

PROS will 1) lead promote and coordinate national research to improve the physical health and well-being of children and adolescents; 2) maintain and augment a national RN infrastructure to support a portfolio of multi-site interdisciplinary research accelerate translation of research to policy and practice and provide a mentoring environment for trainees; 3) advance health equity by conducting research that addresses the needs of underserved and safety net populations; and 4) conduct timely and innovative research in pediatric primary care that addresses HRSA priorities.

Proposed activities and target populations:

PROS will conduct multiple primary care intervention trials of national scope that address the needs of children including the underserved; maintain and innovate the research network building capacity for high impact implementation and dissemination of study findings; and help develop the next generation of leaders in practice-based research. Target populations include children from birth through adolescence their families pediatric clinicians policymakers and other stakeholders.


PROS will continue to link expert researchers with our network of primary care pediatric clinicians. PROS will cultivate connections between pediatric clinicians researchers parents and stakeholders via in-person and virtual meetings. Dissemination and implementation of results will be maximized through linkage to AAP programs and communications.


Products under this proposal include grant submissions externally funded large studies of national scope peer-reviewed publications and presentations tools for clinicians and other pediatric professionals and evidence to inform clinical policy.


Progress is monitored through the number and reach of products tracking of evaluation measures and regular reporting to MCHB.


Nekrasova E, Stockwell M, Localio R, et al. Vaccine hesitancy and influenza beliefs among parents of children requiring a second dose of influenza vaccine in a season: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) study. Human Vaccines & Immunotherapeutics, 2020, Feb 4:1-8. DOI:Human Vaccines & Immunotherapeutics February 2020

Nabi-Burza E, Wasserman R, Drehmer J, et al. Spontaneous Smoking Cessation in Parents. Journal of Smoking Cessation, Vol. 2021, Article ID 5526715, 2021. doi/10.1155/2021/5526715 DOI:10.1155/2021/5526715 May 2021

Szilagyi P, Humiston S, Stephens-Shields A, et al.� Effect of Training Pediatric Clinicians in Human Papillomavirus Communication Strategies on Human Papillomavirus Vaccination Rates: A Cluster Randomized Clinical Trial. JAMA Pediatr. 2021;175(9):901-910. doi:10.1001/jamapediatrics.2021.0766 DOI:10.1001/jamapediatrics.2021.0766 September 2021

Mangione-Smith R, Robinson JD, Zhou C, et al. Fidelity evaluation of the dialogue around respiratory illness treatment (DART) program communication training. Patient Educ Couns. 2022;105(7):2611-2616. doi:10.1016/j.pec.2022.03.011 DOI:10.1016/j.pec.2022.03.011 July 2022 35341612 Patient Educ Couns.

Fiks AG, Stephens-Shields AJ, Kelly MK, et al. Performance Feedback for Human Papillomavirus Vaccination: A Randomized Trial From the American Academy of Pediatrics Pediatric Research in Office Settings Research Network [published online ahead of print, 2022 Jul 16]. Acad Pediatr. 2022;S1876-2859(22)00351-5. doi:10.1016/j.acap.2022.07.006 DOI:10.1016/j.acap.2022.07.006 July 2022 35853600 Acad Pediatr.

Stockwell MS, Shone LP, Nekrasova E, et al. Text Message Reminders for the Second Dose of Influenza Vaccine for Children: An RCT. Pediatrics. 2022;150(3):e2022056967. doi:10.1542/peds.2022-056967 DOI:10.1542/peds.2022-056967 September 2022 35965283 Pediatrics

Fiks A, Hannan C, Localio R, et al. HPV Vaccinations at Acute Visits and Subsequent Adolescent Preventive Visits. Pediatrics 2022; e2022058188. 10.1542/peds.2022-05818 DOI: 10.1542/peds.2022-05818 November 2022 Pediatrics

Gabryszewski J, Dudley J, Shu D, et al. Patterns in the Development of Pediatric Allergy. Pediatrics, 2023 Aug 1;152(2):e2022060531. doi: 10.1542/peds.2022-060531. DOI:doi: 10.1542/peds.2022-060531 August 2023 Pediatrics

Kelly M, Stephens-Shields A, Hannan C, et al. Missed Opportunities for Adolescent Immunizations at Well-Care Visits During the COVID-19 Pandemic. J Adolesc Health. 2023 Sep;73(3):595-598. doi: 10.1016/j.jadohealth.2023.05.008. DOI: doi: 10.1016/j.jadohealth.2023.05.00 September 2023 J Adolesc Health

Moreno M, Klein J, Kaseeska K, et al. A Cluster Randomized Controlled Trial of a Primary Care Provider-Delivered Social Media Counseling Intervention, J Adolesc Health, 2023, Published online August 12, 2023. August 2023 J Adolesc Health

Nekrasova E, Fiks A, Wynn C, et al. Pediatric Practices� Perceptions of Text Message Communication with Families: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) Qualitative Study. ACI Open 2023;7:e8�e15. doi:10.1055/s-0043-1763270. DOI: doi:10.1055/s-0043-1763270 March 2023 ACI Open

Rand C, Stephens-Shields A, Kelly M, et al. Clinician Prompts for Human Papillomavirus Vaccination: A Cluster Randomized Trial. Acad Pediatr. 2023 Nov 2:S1876-2859(23)00401-1. DOI::S1876-2859(23)00401-1. November 2023 Acad Pediatr.

Woolford S, Resnicow K, Davis M, et al. Cost-effectiveness of a motivational interviewing obesity intervention versus usual care in pediatric primary care offices. Obesity. 2022 Nov;30(11):2265-2274. doi: 10.1002/oby.23560. DOI:doi: 10.1002/oby.23560 November 2022 Obesity

Wynn CS, Fiks AG, Localio R, et al. Examination of Text Message Plans and Baseline Usage of Families Enrolled in a Text Message Influenza Vaccine Reminder Trial: Survey Study. JMIR Form Res. 2023;7:e39576. Published 2023 Jun 30. doi:10.2196/39576 June 2023 JMIR Form Res