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Life Course Interventions Research Network (LCI-RN)

Project profile

Institution: The Regents of the University of California
Principal Investigator: Neal Halfon
Project Number: UA6MC32492
Project Date: 09-30-2018

Age Group(s)

  • Women/Maternal
  • Early Childhood (3-5 years)
  • Middle Childhood (6-11 years)
  • Adolescence (12-18 years)
  • Young Adulthood (19-25 years)

Targeted/Underserved Population

  • Low-income
  • Special Health Care Needs


The revolutionary potential of a life course approach has yet to be fully realized due to 1) gaps in our knowledge about how and when to intervene 2) the lack of a strong research and data infrastructure to support life course intervention (LCI) research 3) a shortage of crosssector community-based delivery platforms and flexible funding 4) a failure to give researchers the core capacities to conduct innovative and impactful LCI research 5) a lack of research on how best to combine interventions into a sustainable strategy and 6) a failure to meaningfully engage patients families and communities in research from design through to implementation evaluation and scaling. These issues have hindered the development of innovative and impactful solutions to the enormous challenges facing today's children and families.

Goals and objectives:

(1) Establish and manage a Life Course Intervention Research Network (LCI-RN) Infrastructure and Learning System including a Network Coordinating Center (NCC) and Collaborating Research Entities (CREs); (2) Design develop publish disseminate and regularly update an LCI Research Agenda; (3) Develop and operate an Innovation and Impact Incubator that enables the development of LCI studies; (4) Provide training on priority topics to network members and cultivate a new generation of LCI researchers through an LCI Scholars Program; (5) Utilize a website e-newsletters webinars and publications to accelerate the timely translation of LCI research; and (6) Develop and implement an outreach engagement and fundraising plan to ensure network growth and sustainability.

Proposed activities and target populations:

The network will function as a platform that cultivates and leverages the collective intelligence of a growing and generative LCI research community including scientists methodologists practitioners family members and community residents. As such it will support the relentless pursuit of new ways of improving life course trajectories for diverse populations and communities.


The NCC will be centered at UCLA. Six cores will take responsibility for key network functions with Steering and Advisory Committees engaging researchers from a growing network of universities as well as from organizations like Family Voices AMCHP and CityMatch among others. Five CREs will involve a variety of organizations and existing networks including PEDSnet existing MCH-funded research networks existing communitybased initiatives and the Los Angeles Department of Public Health.


We anticipate producing an LCI research agenda with at least 1 peer-reviewed publication 1 webinar and 3 presentations plus 3 annual updates. We will also incubate 20 studies and ten R01 grant proposals


We will use a combination of process and outcome measures to assess the network and the effectiveness and efficiency in attaining our goals and objectives.


Duh-Leong C, Yin HS, Salcedo V, et al. Infant Feeding Practices and Social Support Networks Among Immigrant Chinese American Mothers With Economic Disadvantage in New York City. Journal of Human Lactation. 2022;0(0). doi:10.1177/08903344221121571 DOI:doi:10.1177/08903344221121571 February 2022 Journal of Human Lactation

Wong MD, Meza BPL, Dosanjh KK, et al. Association of Attending a High-Performing High School with Substance Use Disorder Rate and Health Outcomes in Young Adults. JAMA Netw Open. 2022;5(10):e2235083. doi:10.1001/jamanetworkopen.2022.35083 October 2022

Anderson NW, Eisenberg D, Halfon N, et al.�Trends in Measures of Child and Adolescent Well-being in the US from 2000-2019. JAMA Netw Open. 2022;5(10):e2238582. doi:10.1001/jamanetworkopen.2022.38582 DOI: doi:10.1001/jamanetworkopen.2022.38582 October 2022

Halfon, N., Chandra, A., Cannon, J.S. et al. The Gross Developmental Potential (GDP2): a new approach for measuring human potential and wellbeing. BMC Public Health 22, 1626 (2022). DOI: 2022 BMC Public Health

Wong MD, Meza BPL, Dosanjh KK, et al. Association of Attending a High-Performing High School with Substance Use Disorder Rate and Health Outcomes in Young Adults. JAMA Netw Open. 2022;5(10):e2235083. doi:10.1001/jamanetworkopen.2022.35083 DOI:doi:10.1001/jamanetworkopen.2022.35083 2022 JAMA Netw

Sobotka, SA, Lynch, E, Msall, ME, Graham, RJ. Early childhood developmental skills of children with tracheostomies and ventilators recently discharged home. Pediatric Pulmonology. 2023; 58: 853- 865. doi:10.1002/ppul.26265 DOI:doi:10.1002/ppul.26265 2023 Pediatric Pulmonology

Coates EE, Hayes KR, de Heer R, et al. "It was Just Good to Have an Outlet for Other Parents to Talk to": Feasibility and Acceptability of Integrating Mental Health and Wellness Services into Predominantly Black Early Childhood Education Centers During the COVID-19 Pandemic [published online ahead of print, 2023 Jul 3]. Child Psychiatry Hum Dev. 2023;10.1007/s10578-023-01563-4. doi:10.1007/s10578-023-01563-4 DOI:doi: 10.1007/s10578-023-01563-4 July 2023 37395925

Moore C, Coates E, Watson A, de Heer R, McLeod A, Prudhomme A. "It's Important to Work with People that Look Like Me": Black Patients' Preferences for Patient-Provider Race Concordance [published online ahead of print, 2022 Nov 7] [published correction appears in J Racial Ethn Health Disparities. 2022 Dec 19;:]. J Racial Ethn Health Disparities. 2022;1-13. doi:10.1007/s40615-022-01435-y DOI:doi: 10.1007/s40615-022-01435-y November 2022 36344747

Duh-Leong C, Fuller AE, Johnson SB, Coble CA, Nagpal N, Gross RS. Social Capital and Sleep Outcomes Across Childhood in United States Families [published online ahead of print, 2023 Jan 11]. Acad Pediatr. 2023;S1876-2859(23)00001-3. doi:10.1016/j.acap.2023.01.002 DOI:doi: 10.1016/j.acap.2023.01.002 January 2023 36641090

Childress S, Roberts A, LaBrenz CA, Findley E, Ekueku M, Baiden P. Exploring the lived experiences of women with children during COVID-19: Maternal stress and coping mechanisms. Child Youth Serv Rev. 2023;145:106775. doi:10.1016/j.childyouth.2022.106775 DOI:doi: 10.1016/j.childyouth.2022.106775 February 2023 36575706

Duh-Leong C, Ghassabian A, Kannan K, et al. Prenatal oxidative stress and rapid infant weight gain [published online ahead of print, 2023 Apr 3]. Int J Obes (Lond). 2023;10.1038/s41366-023-01302-8. doi:10.1038/s41366-023-01302-8 DOI:doi: 10.1038/s41366-023-01302-8 July 2023 37012425

Clemmons NG, Coates E, McLeod, A. Understanding the benefits of child-parent psychotherapy delivered via telehealth during the COVID-19 pandemic, 2023; Children's Health Care, DOI: 10.1080/02739615.2023.2179489 DOI:doi: 10.1080/02739615.2023.2179489 February 2023

Anderson NW, Russ SA, Eisenberg D, Halfon N. Dashboards as Mechanisms for Community Empowerment: Developing a Prototype for Child and Adolescent Well-being in California. J Public Health Manag Pract. 2023;29(4):529-538. doi:10.1097/PHH.0000000000001746 DOI:doi: 10.1097/PHH.0000000000001746 July 2023 37200100

Cher X. Huang, Neal Halfon, Narayan Sastry, Paul J. Chung, Adam Schickedanz; Positive Childhood Experiences and Adult Health Outcomes. Pediatrics July 2023; 152 (1): e2022060951. 10.1542/peds.2022-060951 DOI:doi: 10.1542/peds.2022-060951 June 2023

Gallego Clemmons N, Coates EE, McLeod A. Understanding the benefits of child-parent psychotherapy delivered via telehealth during the COVID-19 pandemic. Children�s Health Care. 2023. doi: 10.1080/02739615.2023.2179489 DOI:doi: 10.1542/peds.2022-060951 February 2023

Meza BPL, Dudovitz RN, Cooper ZD, Tucker JS, Wong MD. Adolescent Cannabis Misuse Scale: Longitudinal Associations with Substance Use, Mental Health, and Social Determinants of Health in Early Adulthood. Subst Use Misuse. 2023;58(9):1080-1089. doi:10.1080/10826084.2023.2201852 May 2023 37088737

Duh-Leong C, Perrin EM, Heerman WJ, Schildcrout JS, Wallace S, Mendelsohn AL, Lee DC, Flower KB, Sanders LM, Rothman RL, Delamater AM, Gross RS, Wood C, Yin HS. Prenatal Risks to Healthy Food Access and High Birthweight Outcomes. Acad Pediatr. 2023 Sep 1:S1876-2859(23)00346-7. doi: 10.1016/j.acap.2023.08.017. Epub ahead of print. PMID: 37659601. September 2023

Childress, S., LaBrenz, C. A., Findley, E., & Baiden, P. (2023). Adjusting Parenting Roles and Work Expectations Among Women With Children During COVID-19. Families in Society, 0(0). DOI: 2023

Kim L, Duh-Leong C, Nagpal N, Ortiz R, Katzow MW, Russ S, Halfon N. Supporting early childhood routines to promote cardiovascular health across the life course. Curr Probl Pediatr Adolesc Health Care. 2023 Oct 9:101434. doi: 10.1016/j.cppeds.2023.101434. Epub ahead of print. PMID: 37821292. DOI:doi: 10.1016/j.cppeds October 2023 37821292. Curr Probl Pediatr Adolesc Health Care

Tolliver DG, Abrams LS, Biely C, Meza BPL, Schickedanz A, Guerrero AD, Jackson NJ, Bath E, Heard-Garris N, Dudovitz R, Barnert E. United States Youth Arrest and Health Across the Life Course: A Nationally Representative Longitudinal Study. Acad Pediatr. 2023 May-Jun;23(4):722-730. doi: 10.1016/j.acap.2022.08.009. Epub 2022 Aug 31. PMID: 36055448; PMCID: PMC9971348. August 2023 36055448

Rook JM, Yama CL, Schickedanz AB, Feuerbach AM, Lee SL, Wisk LE. Changes in Self-Reported Adult Health and Household Food Security With the 2021 Expanded Child Tax Credit Monthly Payments. JAMA Health Forum. 2023 Jun 2;4(6):e231672. doi: 10.1001/jamahealthforum.2023.1672. PMID: 37354539; PMCID: PMC10290752. DOI: doi: 10.1001/jamahealthforum.2023. June 2023 37354539 JAMA Health Forum.

Rodriguez SH, Blair MP, Timtim E, Millman R, Si Z, Wroblewski K, Andrews B, Msall ME, Peyton C. Smartphone application links severity of retinopathy of prematurity to early motor behavior in a cohort of high-risk preterm infants. J AAPOS. 2023 Feb;27(1):12.e1-12.e7. doi: 10.1016/j.jaapos.2022.11.018. Epub 2023 Jan 13. PMID: 36642242; PMCID: PMC10243477. DOI: doi: 10.1016/j.jaapos.2022 January 2023 36642242

Duh-Leong C, Canfield CF, Fuller AE, Gross RS, Reichman NE. Early Childcare Precarity and Subsequent Maternal Health. Womens Health Issues. Published online November 15, 2023. doi:10.1016/j.whi.2023.10.002 DOI:doi:10.1016/j.whi.2023.10.002 November 2023 Womens Health Issues

La Charite J, Khan M, Dudovitz R, et al. Specific domains of positive childhood experiences (PCEs) associated with improved adult health: A nationally representative study. SSM Popul Health. 2023;24:101558. Published 2023 Nov 11. doi:10.1016/j.ssmph.2023.101558 DOI:doi:10.1016/j.ssmph.2023.101558 November 2023 SSM Popul Health.

Arons A, Schickedanz A, Halfon N. Using a Life Course Health Development Framework to Redesign Medicaid [published online ahead of print, 2021 Sep 20].�Acad Pediatr. 2021;S1876-2859(21)00449-6. doi:10.1016/j.acap.2021.09.008 September 2021

Dudovitz RN, Russ S, Berghaus M,�et al.�COVID-19 and Children�s Well-Being: A Rapid Research Agenda.�Matern Child Health J�25,�1655�1669 (2021). August 2021

Arons A, Schickedanz A, Halfon N. (2022) Using a Life Course Health Development Framework to Redesign Medicaid. Academic Pediatrics. 22(3);367-73 DOI:10.1016/j.acap.2021.09.008 April 2022 34547520

Barkin S, Verbiest S, Berge J. Using the Tools of Today to Advance the Life Course Interventions of Tomorrow. Pediatrics. 2022;149(Suppl 5):e2021053509N. Doi:10.1542/peds.2021-053509N DOI:10.1542/peds.2021-053509N May 2022 35503313

Barnert ES, Gallagher D, Lei H, Abrams LS. Applying a Health Development Lens to Canada's Youth Justice Minimum Age Law. Pediatrics. 2022;149(Suppl 5):e2021053509P. Doi:10.1542/peds.2021-053509P DOI:10.1542/peds.2021-053509P May 2022 35503317

Buka SL, Beers LS, Biel MG, et al. The Family is the Patient: Promoting Early Childhood Mental Health in Pediatric Care. Pediatrics. 2022;149(Suppl 5):e2021053509L. Doi:10.1542/peds.2021-053509L DOI:10.1542/peds.2021-053509L May 2022 35503309

Chandler A. Striving and Thriving: A Life Course Trade-Off?. Pediatrics. 2022;149(Suppl 5):e2021053509Q. Doi:10.1542/peds.2021-053509Q DOI:10.1542/peds.2021-053509Q May 2022 35503319

Dudovitz RN, Russ S, Berghaus M, et al. COVID-19 and Children's Well-Being: A Rapid Research Agenda. Matern Child Health J. 2021;25(11):1655-1669. doi:10.1007/s10995-021-03207-2 DOI:10.1007/s10995-021-03207-2 November 2022 34427834

Feinberg M, Hotez E, Roy K, et al. Family Health Development: A Theoretical Framework. Pediatrics. 2022;149(Suppl 5):e2021053509I. Doi:10.1542/peds.2021-053509I DOI:10.1542/peds.2021-053509I May 2022 35503316

Findley E, LaBrenz CA, Childress S, V�squez-Schut G, Bowman K. 'I'm not perfect': Navigating screen time among parents of young children during COVID-19 [published online ahead of print, 2022 Aug 10]. Child Care Health Dev. 2022;10.1111/cch.13038. doi:10.1111/cch.13038 DOI:10.1111/cch.13038 August 2022 35950221

Foney DM, DiBari J, Li R, Kogan M. Life Course Investments at the Maternal and Child Health Bureau. Pediatrics. 2022;149(Suppl 5):e2021053509B. Doi:10.1542/peds.2021-053509B DOI:10.1542/peds.2021-053509B May 2022 35503312

Halfon N, Russ SA, Kahn RS. Inequality and child health: dynamic population health interventions. Curr Opin Pediatr. 2022;34(1):33-38. doi:10.1097/MOP.0000000000001087 DOI:10.1097/MOP.0000000000001087 February 2022 34879028

Halfon N, Russ SA, Schor EL. The Emergence of Life Course Intervention Research: Optimizing Health Development and Child Well-Being. Pediatrics. 2022;149(Suppl 5):e2021053509C. Doi:10.1542/peds.2021-053509C DOI:10.1542/peds.2021-053509C May 2022 35503314

Hoover C, Ware A, Serano A, Verbiest S. Engaging Families in Life Course Intervention Research: An Essential Step in Advancing Equity. Pediatrics. 2022;149(Suppl 5):e2021053509G. Doi:10.1542/peds.2021-053509G DOI:10.1542/peds.2021-053509G May 2022 35503310

Hotez E, Berghaus M, Verbiest S, Russ S, Halfon N. Proposal for Life Course Intervention Researcher Core Competencies. Pediatrics. 2022;149(Suppl 5):e2021053509F. Doi:10.1542/peds.2021-053509F DOI:10.1542/peds.2021-053509F May 2022 35503320

Liu PY, Beck AF, Lindau ST, et al. A Framework for Cross-Sector Partnerships to Address Childhood Adversity and Improve Life Course Health. Pediatrics. 2022;149(Suppl 5):e2021053509O. Doi:10.1542/peds.2021-053509O DOI:10.1542/peds.2021-053509O May 2022 35503315

McKenzie K, Lynch E, Msall ME. Scaffolding Parenting and Health Development for Preterm Flourishing Across the Life Course. Pediatrics. 2022;149(Suppl 5):e2021053509K. Doi:10.1542/peds.2021-053509K DOI:10.1542/peds.2021-053509K May 2022 35503323

Ozer EJ, Sprague Martinez L, Abraczinskas M, Villa B, Prata N. Toward Integration of Life Course Intervention and Youth Participatory Action Research. Pediatrics. 2022;149(Suppl 5):e2021053509H. Doi:10.1542/peds.2021-053509H DOI:10.1542/peds.2021-053509H May 2022 35503322

Ramaswami SB, Jensen T, Berghaus M, et al. Family Health Development in Life Course Research: A Scoping Review of Family Functioning Measures. Pediatrics. 2022;149(Suppl 5):e2021053509J. Doi:10.1542/peds.2021-053509J DOI:10.1542/peds.2021-053509J May 2022 35503321

Russ SA, Hotez E, Berghaus M, et al. Building a Life Course Intervention Research Framework. Pediatrics. 2022;149(Suppl 5):e2021053509E. Doi:10.1542/peds.2021-053509E DOI:10.1542/peds.2021-053509E May 2022 35503325

Russ SA, Hotez E, Berghaus M, et al. What Makes an Intervention a Life Course Intervention?. Pediatrics. 2022;149(Suppl 5):e2021053509D. Doi:10.1542/peds.2021-053509D DOI:10.1542/peds.2021-053509D May 2022 35503318

Wake M, Goldfeld S, Davidson A. Embedding Life Course Interventions in Longitudinal Cohort Studies: Australia's GenV Opportunity. Pediatrics. 2022;149(Suppl 5):e2021053509R. Doi:10.1542/peds.2021-053509R DOI:10.1542/peds.2021-053509R May 2022 35503324

Wong MD, Quartz KH, Saunders M, et al. Turning Vicious Cycles Into Virtuous Ones: the Potential for Schools to Improve the Life Course. Pediatrics. 2022;149(Suppl 5):e2021053509M. Doi:10.1542/peds.2021-053509M DOI:10.1542/peds.2021-053509M May 2022 35503311

"Dudovitz RN, Russ S, Berghaus M, et al. COVID-19 and Children's Well-Being: A Rapid Research Agenda. Matern Child Health J. 2021;25(11):1655-1669. doi:10.1007/s10995-021-03207-2 " DOI:10.1007/s10995-021-03207-2 November 2022 34427834

Liu PY, Spiker S, Holguin M, Schickedanz A. Innovations in social health delivery to advance equitable pediatric and adolescent life course health development: A review and roadmap forward. Curr Probl Pediatr Adolesc Health Care. 2023;53(6):101451. doi:10.1016/j.cppeds.2023.101451 DOI:doi:10.1016/j.cppeds.2023.101451 June 2023 Curr Probl Pediatr Adolesc Health Care

Lesnick J, Abrams LS, Angel K, Barnert ES. Credible messenger mentoring to promote the health of youth involved in the juvenile legal system: A narrative review. Curr Probl Pediatr Adolesc Health Care. 2023;53(6):101435. doi:10.1016/j.cppeds.2023.101435 DOI:doi:10.1016/j.cppeds.2023.101435 June 2023 Curr Probl Pediatr Adolesc Health Care

Barnert ES, Schlichte LM, Tolliver DG, et al. Parents' Adverse and Positive Childhood Experiences and Offspring Involvement With the Criminal Legal System. JAMA Netw Open. 2023;6(10):e2339648. Published 2023 Oct 2. doi:10.1001/jamanetworkopen.2023.39648 DOI:doi:10.1001/jamanetworkopen.2023.39648 October 2023 JAMA

Crandall, A., Holmes, E. K., Villalon, S. E., Weiss-Laxer, N. S., & Berge, J. M. (2023). A conceptual model of family well-being: Bridging constructs, fields, and practice applications. Journal of Family Theory & Review, 1�18. DOI: 2023 Journal of Family Theory & Review