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Autism Intervention Research Network on Physical Health (AIR-P Network)
Project Number: UA3 MC 11054
Grantee: Massachusetts General Hospital
Project Date: 9/1/2008
Karen Kuhlthau, PhD
Associate Professor of Pediatrics
100 Cambridge Street 15th Floor
Boston, MA 02114
- Toddlerhood (13-35 months)
- Early Childhood (3-5 years)
- Middle Childhood (6-11 years)
- Adolescence (12-18 years)
Problem: Children and adolescents with autism spectrum disorders (ASD) often experience symptoms associated with underlying medical conditions that may affect their health and wellbeing. Families face substantial difficulty accessing adequate health care, particularly families from underserved groups. Purpose: To improve the physical health and well-being of children and adolescents with ASD or other developmental disabilities by expanding and continuing the work of the AIR-P. The network will advance HRSA’s goal of addressing disparities and improving health equity by focusing on individuals from underserved populations across the U.S. Goals and Objectives: AIR-P aims to: 1) conduct multisite research on evidence-based interventions that improve physical health of children and adolescents with ASD and developmental disorders, especially underserved populations; 2) transform AIR-P into a multisite Learning Network (LN) which will provide a collaborative laboratory for developing and testing evidence-based interventions and accelerating the adoption of effective interventions to improve care and reduce disparities; 3) support development and mentorship of emerging or new investigators; 4) develop and disseminate guidelines for interventions; 5) accelerate the adoption of effective interventions into practice settings and communities, especially underserved communities; and 6) leverage network capacity to compete for grant opportunities from other Federal and private sources. Proposed Activities and Target Population(s): We will conduct two core multisite research initiatives: 1) ECHO Autism, an intervention to teach PCPs to improve their care of children with ASD, and 2) a study aimed at improving participation in dental care and oral health outcomes for underserved children with ASD. These projects target children with ASD with an emphasis on those from underserved groups including children from practices for which over 50% of patients are underserved (for ECHO Autism) and patients with Medicaid insurance (the Dental project). We will also provide opportunities to support secondary data analyses of ATN Registry data as well as pilot studies. We will transform AIR-P into a Learning Network that will include cycles of tests of change and spread of successful interventions to underserved communities, complete guidelines, and disseminate findings at a national level. Coordination: The interdisciplinary team includes clinicians from diverse specialties, health policy experts, researchers, and family members. Our partnership with the Massachusetts League of Community Health Centers (the League) will allow the AIR-P to coordinate the recruitment of patients, pediatricians, and practices to our research studies. We will also partner with community organizations that serve diverse communities.
Listed is descending order by year published.
Marler S, Ferguson BJ, Lee EB, et al. Brief report: whole blood serotonin levels and gastrointestinal symptoms in Autism Spectrum Disorder. J Autism Dev Disord. 2016;46(3):1124-1130.
de Vinck-Baroody O, Shui A, Macklin EA, Hyman SL, et al. Overweight and obesity in a sample of children with Autism Spectrum Disorder. Academic pediatrics. 2015;15(4):396-404.
DeMand A, Johnson C, Foldes E. Psychometric properties of the Brief Autism Mealtime Behaviors Inventory. J Autism Dev Disord. 2015;45(9):2667-2673.
Hill AP, Zuckerman KE, Fombonne E. Obesity and autism. Pediatrics. 2015;136:1051.
Johnson CR, DeMand A, Shui A. Relationships between anxiety and sleep and feeding in young children with ASD. J Dev Phys Disabil. 2015;27(3):359-373.
Kuhlthau KA, Warfield ME, Hurson J, Delahaye J, et al. Pediatric provider's perspectives on the transition to adult health care for youth with autism spectrum disorder: current strategies and promising new directions. Autism. 2015;19(3):262-271.
Mazurek MO, Petroski GF. Sleep problems in children with autism spectrum disorder: examining the contributions of sensory over-responsivity and anxiety. Sleep Med. 2015;16(2):270-279.
Stewart PA, Hyman SL, Schmidt BL, et al. Dietary supplementation in children with Autism Spectrum Disorders: common, insufficient, and excessive. J Acad Nutr Diet. 2015;115(8):1237-48.
Vasa RA, Mazurek MO. An update on anxiety in youth with autism spectrum disorders. Curr Opin Psychiatry. 2015;28(2):83-90.
Veatch OJ, Reynolds A, Katz T, et al. Sleep in children with Autism Spectrum Disorders: how are measures of parent report and actigraphy related and affected by sleep education? Behav Sleep Med. 2015;1-12.
Warfield ME, Crossman MK, Delahaye J, Der Weerd E, et al. Physician perspectives on providing primary medical care to adults with Autism Spectrum Disorders (ASD). J Autism Dev Disord. 2015;45:2209-2217.
Hill AP, Zuckerman KE, Hagen AD, et al. Aggressive behavior problems in children with autism spectrum disorders: prevalence and correlates in large clinical sample. Res Autism Spectr Disord. 2014;8(9):1121-33.
Hoefman R, Payakachat N, van Exel J, et al. Caring for a child with autism spectrum disorder and parents’ quality of life: application of the CarerQol. J Autism Dev Disord. 2014;44(8):1933-45.
Johnson CR, Turner K, Stewart PA, et al. Relationship between feeding problems, behavioral characteristics, and nutritional quality in children with ASD. J Autism Dev Disord. 2014;44(9):2175-84.
Kanne SM, Mazurek MO, Sikora D, Bellando J, Branum-Martin L, Handen B, Katz T, Freedman B, Powell MP, Warren Z. The Autism Impact Measure (AIM): Initial development of a new tool for treatment outcome measurement. J Autism Dev Disord. 2014;44(1):168-79.
Malow BA, Adkins KW, Reynolds A, Weiss SK, Loh A, Fawkes D, Katz T, Goldman SE, Madduri N, Hundley R, Clemons T. Parent-based sleep education for children with autism spectrum disorders. J Autism Dev Disord. 2014 ;44(1):216-28.
Mazurek MO, Keefer A, Shui A, Vasa RA. One-year course and predictors of abdominal pain in children with autism spectrum disorders: the role of anxiety and sensory over-responsivity. Res Autism Spect Dis. 2014;8(11):1508-15.
Payakachat N, Tilford JM, Kuhlthau KA, et al. Predicting health utilities for children with autism spectrum disorders. Autism Res. 2014;7(6):649-63.
Vasa RA, Carroll LM, Nozzolillo AA, et al. A systematic review of treatments for anxiety in youth with autism spectrum disorders. J Autism Dev Disord. 2014;44(12):3215-29.
Zuckerman KE, Hill AP, Guion K, Voltolina L. Overweight and obesity: prevalence and correlates in a large clinical sample of children with autism spectrum disorder. J Autism Dev Disord. 2014;44(7):1708-19.
Ameis SH, Corbett-Dick P, Cole L, Correll CU. Decision making and antipsychotic medication treatment for youth with autism spectrum disorders: applying guidelines in the real world. J Clin Psychiatry. 2013;74(10):1022-4.
Coury DL. DSM-5 and autism spectrum disorders: implications for families and clinicians. J Dev Behav Pediatr. 2013;34(7):494-6.
Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, James SJ. Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders. Autism Res Treat. 2013;2013:578429.
Kaat AJ, Lecavalier L, Aman MG. Validity of the Aberrant Behavior Checklist in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2013 Oct 29. [Epub ahead of print] PubMed PMID: 24165702.
Mazurek MO, Kanne SM, Wodka EL. Physical aggression in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders. 2013;7(3):455-65.
Mazurek MO, Vasa RA, Kalb LG, Kanne SM, Rosenberg D, Keefer A, Murray DS, Freedman B, Lowery LA. Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders. J Abnorm Child Psychol. 2013;41(1):165-76.
Peters B, Williams KC, Gorrindo P, Rosenberg D, Lee EB, Levitt P, Veenstra-Vanderweele J. Rigid-Compulsive Behaviors are Associated with Mixed Bowel Symptoms in Autism Spectrum Disorder. J Autism Dev Disord. 2013 Nov 29. [Epub ahead of print] PubMed PMID: 24293040.
Sikora D, Moran E, Orlich F, et al. The relationship between family functioning and behavior problems in children with autism spectrum disorders. Research in Autism Spectrum Disorders. 2013;7(2):307-15.
Adkins KW, Goldman SE, Fawkes D, et al. A pilot study of shoulder placement for actigraphy in children. Behavioral Sleep Medicine. 2012;10(2):138-47.
Adkins KW, Molloy C, Weiss SK, et al. Effects of a standardized pamphlet on insomnia in children with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S139-44.
Coury DL, Anagnostou E, Manning-Courtney P, et al. Use of psychotropic medication in children and adolescents with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S69-76.
Coury DL, Ashwood P, Fasano A, et al. Gastrointestinal conditions in children with autism spectrum disorder: Developing a research agenda. Pediatrics. 2012;130(Suppl 2):S160-8.
Furuta GT, Williams K, Kooros K, et al. Management of constipation in children and adolescents with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S98.
Goldman SE, Richdale AL, Clemons T, Malow BA. Parental sleep concerns in autism spectrum disorders: variations from childhood to adolescence. J Autism Dev Disord. 2012;42(4):531-8.
Hyman SL, Stewart PA, Schmidt B, et al. Nutrient intake from food in children with autism. Pediatrics. 2012;130(Suppl 2):S145-53.
Lajonchere C, Jones N, Coury DL, Perrin JM. Leadership in health care, research, and quality improvement for children and adolescents with autism spectrum disorders: Autism treatment network and autism intervention research network on physical health. Pediatrics. 2012;130(Suppl 2):S62-8.
Mahajan R, Bernal MP, Panzer R, et al. Clinical practice pathways for evaluation and medication choice for attention-deficit/hyperactivity disorder symptoms in autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S125-38.
Malow BA, Byars K, Johnson K, et al. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S106-24.
Neumeyer AM, Gates A, Ferrone C, Lee H, Misra M. Bone Density in Peripubertal Boys with Autism Spectrum Disorders. J Autism Dev Disord. 2012 Nov 4. [Epub ahead of print] PubMed PMID: 23124396.
Perrin JM, Coury DL, Hyman SL, Cole L, Reynolds AM, Clemons T. Complementary and alternative medicine use in a large pediatric autism sample. Pediatrics. 2012;130(Suppl 2):S77-82.
Perrin JM, Coury DL, Jones N, Lajonchere C. The autism treatment network and autism intervention research network on physical health: Future directions. Pediatrics. 2012;130(Suppl 2):S198-201.
Perrin JM, Coury DL. Improving health care for children and youth with autism and other neurodevelopmental disorders. editors' note and prologue. Pediatrics. 2012;130(Suppl 2):S57-8.
Reynolds A, Krebs NF, Stewart PA, Austin H, Johnson SL, Withrow N, Molloy C, James SJ, Johnson C, Clemons T, Schmidt B, Hyman SL. Iron status in children with autism spectrum disorder. Pediatrics. 2012 Nov;130 Suppl 2:S154-9.
Sikora DM, Johnson K, Clemons T, Katz T. The relationship between sleep problems and daytime behavior in children of different ages with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S83-90.
Sikora DM, Vora P, Coury DL, Rosenberg D. Attention-deficit/hyperactivity disorder symptoms, adaptive functioning, and quality of life in children with autism spectrum disorder. Pediatrics. 2012;130(Suppl 2):S91-7.
Tilford JM, Payakachat N, Kovacs E, et al. Preference-based health-related quality-of-life outcomes in children with autism spectrum disorders: A comparison of generic instruments. Pharmacoeconomics. 2012;30(8):661-9.
Coury D. Very little high-quality evidence to support most medications for children with autism spectrum disorders. J Pediatr. 2011;159(5):872-3.
Coury DL. Review: Little evidence of clear benefit for most medical treatments for children with autism spectrum disorders. Evid Based Ment Health. 2011;14(4):105.
Goldman S, McGrew S, Johnson K, Richdale A, Clemons T, & Malow B. Sleep is associated with problem behaviors in children and adolescents with autism spectrum disorders. Res Autism Spectr Disord. 2011;5(3):1223-9.
Kanne SM, Mazurek MO. Aggression in children and adolescents with ASD: Prevalence and risk factors. J Autism Dev Disord. 2011;41(7):926-37.
Perrin JM, Kolls JK, Coury DL. Evidence-based practice and health advocacy organizations. JAMA. 2011 Oct 5;306(13):1443;author reply 1444-5.
Perrin, JM. Children with special health care needs and changing policy. Acad Pediatr. 2011;11(2):103-4.
Coury D, Jones NE, Klatka K, Winklosky B, Perrin JM. Healthcare for children with autism: the Autism Treatment Network. Curr Opin Pediatr, 2009;21(6):828-32.
Kogan MD, Blumberg SJ, Schieve LA, Boyle CA, Perrin JM, Ghandour RM, et al. Prevalence of parent‐reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics. 2009;124(5):1395-403.
Autism, Nutrition & Diet, Sleep, Clinical Practice, Developmental Disabilities, Special Health Care Needs