The Epidemiology of Abruptio Placentae
Grantee: Swedish Medical Center
Principal Investigator: Michelle Williams
Project Number: R40MC00187
Project Date: 09/01/2000
Age group(s)
- Women/Maternal
- Prenatal
Abstract
Abruptio placentae (AP), the premature separation of the normally implanted placenta before delivery of the infant, is a life threatening obstetric complication for both mother and fetus. Low maternal intake of folate and other B vitamins and maternal iron deficiency anemia may be associated with an increased risk of AP. However, the etiology of AP is unknown. This investigation seeks to study the epidemiology of AP by utilizing an existing maternal second trimester serum repository, state vital records data, and a hospital discharge diagnosis database. The study will assess the relation between risk of AP and biological markers of low folate, vitamin B6, vitamin B12, and iron. Metabolic consequences of low folate and other B vitamins in relation to risk of AP will also be evaluated. Results of this study may increase the ability to identify pregnant women at increased risk of experiencing AP, to further understand the mechanisms by which AP occurs, and to develop alternative, preventative interventions for AP.<< Previous Next >>