Office of Epidemiology and Research, Division of Research

Advancing Applied MCH Research

National Research Network To Improve Child Health

Funded Projects Search


Project Number: UA6MC15585
Grantee: American Academy of Pediatrics
Department/Center: Department of Research / Primary Care Research
Project Date: 09/01/2009
Principal Investigator: Richard C. (Mort) Wasserman

Final Report



  • Perinatal/Infancy (0-12 months)
  • Toddlerhood (13-35 months)
  • Early Childhood (3-5 years)
  • Middle Childhood (6-11 years)
  • Adolescence (12-18 years)


PROBLEM: The paucity of knowledge derived from research in primary care, the consequent lack of guideline credibility for primary care practitioners, and practitioners' sub-optimal adherence to guidelines leads to adverse effects on the quality of care and the health of children. The work of this project directly addresses the following MCH Strategic Research Issues: #I Public health service systems and infrastructures at the community, state and/or national levels, as they apply to different maternal and child health populations based on demographic, epidemiological, and/or other factors; #II MCH services and systems of care efforts to eliminate health disparities and barriers to health care access for MCH populations; #III. Services and systems to assure quality of care for MCH populations; #IV. Promoting the healthy development of MCH populations. GOAL(S) AND OBJECTIVES: Pediatric Research in Office Settings (PROS), the AAP's national research network of pediatric primary care practitioners, will address these problems by accomplishing the following goals: (1) Develop new research ideas and conduct research on critical child health issues; (2) Promote and inform the development of evidence-based guidelines through network research for use by practitioners to improve child health care services; (3) Disseminate critical information on research findings and guidelines developed to child health professionals, policy makers, and the public. METHODOLOGY: Pediatric Research in Office Settings (PROS), a practice-based research network of the AAP, conducts research to address project goals and objectives. New projects are developed at semi-annual meetings of state representatives. PROS practitioners collect research data in community-based pediatric practice sites. Research staff analyze data and report results. COORDINATION: Results are used to inform guidelines and policies and are disseminated via publications and through collaborations with policymakers, educators, and leadership at the American Academy of Pediatrics. EVALUATION: Progress towards achievement of project objectives is monitored through tracking of evaluation measures and regular reporting to MCHB.


Listed is descending order by year published.

Czaja AS, Ross ME, Liu W, Fiks AG, Localio R, Wasserman RC, Grundmeier RW, Adams WG; Comparative Effectiveness Research through Collaborative Electronic Reporting (CER2) Consortium. Electronic health record (EHR) based postmarketing surveillance of adverse events associated with pediatric off-label medication use: A case study of short-acting beta-2 agonists and arrhythmias. Pharmacoepidemiol Drug Saf. 2018 May 27. [Epub ahead of print]

Czaja AS, Fiks AG, Wasserman RC, Valuck RJ; Comparative Effectiveness Research Through Collaborative Electronic Reporting (CER2) Consortium. Beyond the Label: Steering the Focus Toward Safe and Effective Prescribing. Pediatrics. 2017 May;139(5)

Daymont C, Ross ME, Russell Localio A, Fiks AG, Wasserman RC, Grundmeier RW. Automated identification of implausible values in growth data from pediatric electronic health records. J Am Med Inform Assoc. 2017 Nov 1;24(6):1080-1087

Drehmer JE, Hipple B, Ossip DJ, Nabi-Burza E, Winickoff JP. A cross-sectional study of happiness and smoking cessation among parents. J Smok Cessat. 2017;12(1):6-14.

Fiks AG, DuRivage N, Mayne SL, et al. Adoption of a portal for the primary care management of pediatric asthma: A mixed-methods implementation study. Journal of Medical Internet Research. 2016;18(6):e172.

Fiks AG, Scheindlin B, Shone L. 30th anniversary of pediatric research in office settings (PROS): An invitation to become engaged. PEDIATRICS. 2016;138(3):e20161126.

Lee JM, Wasserman R, Kaciroti N, et al. Timing of puberty in overweight versus obese boys. PEDIATRICS. 2016;137(2):e20150164-e20150164.

Resnicow K, Harris D, Wasserman R, et al. Advances in Motivational interviewing for pediatric obesity. Pediatric Clinics of North America. 2016;63(3):539-562.

Shope JT, Zakrajsek JS, Finch S, et al. Translation to primary care of an effective teen safe driving program for parents. Clinical Pediatrics. 2016;55(11):1026-1035.

Drehmer JE, Hipple B, Nabi-Burza E, et al. Proactive enrollment of parents to tobacco quitlines in pediatric practices is associated with greater quitline use: A cross-sectional study. BMC Public Health. 2016;16:520.

Fiks AG, Ross ME, Mayne SL, et al. Preschool ADHD diagnosis and stimulant use before and after the 2011 AAP practice guideline. Pediatrics. 2016;138(6):e20162025.

Kaelber DC, Liu W, Ross M, et al. Diagnosis and medication treatment of pediatric hypertension: a retrospective cohort study. Pediatrics. 2016;138(6); e20162195.

Lee J, Wasserman R, Kaciroti N, et al. Timing of puberty in overweight versus obese boys. Pediatrics. 2016;137(2): e20150164.

Mayne S, Ross M, Song L, et al. Variations in mental heatlth diagnosis and prescribing across pediatric primary care practices. Pediatrics. 2016;137(5): e20152974.

Dempsey J, Regan S, Drehmer JE, et al. Black versus white differences in rates of addressing parental tobacco use in the pediatric setting. Acad Pediatr. 2015;15(1):47-53.

Fiks AG, Grundmeier RW, Steffes J, et al. Comparative effectiveness research through a collaborative electronic reporting consortium. Pediatrics. 2015;136(1): e215-e224.

Fiks AG, Mayne SL, Song L, et al. Changing patterns of alpha agonist medicationi use in children 2009-2011. J Child Adolesc Psychopharmacol. 2015;25(4):362-367.

Fiks AG. Centralized reminder/recall: collaboration to promote the effective use of technology. JAMA Pediatr. 2015;169(4):314-316.

Finch SA, Wasserman R, Nabi-Burza E, Hipple B, Oldendick R, Winickoff JP. Overcoming the challenges in the changing environment of practice-based research. Ann Fam Med. 2015; 13(5) 475-479.

Grundmeier R, Song L, Ramos M, et al. Imputing missing race/ethnicity in pediatric electronic health records: reducing bias with use of the US Census location and surname data. Health Serv Res. 2015;50(4):946-960.

Miller D, Noonan K, Fiks AG, Lehmann CU. Increasing pediatrician participation in EHR incentive programs. Pediatrics. 2015;135(1):e1-e4.

Resnicow K, McMaster F, Bocian A, et al. Motivational interviewing and dietary counseling for obesity in primary care: an RCT. Pediatrics. 2015;135(4):649-657.

Drehmer JE, Ossip DJ, Nabi-Burza E, et al. Thirdhand smoke beliefs of parents. Pediatrics. 2014;133(4):e850-e856.

Fiks AG, Grundmeier RW. Elucidating challenges and opportuniites in the transition to ICD-10-CM. Pediatrics. 2014;134(1)169-170.

Gorzkowski JA, Klein JD, Harris DL, et al. Maintenance of certification part 4 credit and recruitment for practice-based research. Pediatrics. 2014;134(4):747-753.

Winickoff JP, Nabi-Burza E, Chang Y, et al. Sustainability of a parental tobacco control intervention in pediatric practice. Pediatrics. 2014;134(5):933-941.

Bernstein HH, Spino C, Lalama CM, Finch S, Wasserman R, McCormick MC. Unreadiness for Postpartum Discharge Following Healthy Term Pregnancy: Impact on Health Care Use and Outcomes. Academic Pediatrics. 2013;13(1):27-39.

Friebely JF, Rigotti NA, Chang Y, et al. Parent smoker role conflict and planning to quit smoking: a cross-sectional study BMC Public Health 2013, 13:164.

Nabi-Burza E, Winickoff JP, Finch S, Regan S. Triple tobacco screen: opportunity to help families become smokefree. Am J Prev Med. 2013 Dec;45(6):728-731.

Ossip DJ, Chang Y, Nabi-Burza E, et al. Strict smoke-free home policies among smoking parents in pediatric settings. Acad Pediatr. 2013 Nov-Dec;13(6):517-523.

Winickoff JP, Nabi-Burza E, Chang Y, Finch S, Regan S, Wasserman M, Ossip D, Woo H, Klein J, Dempsey J, Drehmer J, Hipple B, Weiley V, Murphy S, Rigotti N. Implementation of a Parental Tobacco Control Intervention in Pediatric Practice. Pediatrics. 2013; 132(1):109-117.

Drehmer JE, Ossip DJ, Rigotti NA, et al. Pediatrician interventions and thirdhand smoke beliefs of parents. Am J Prev Med. 2012; 43(5): 533-536.

Fiks AG, Grundmeier RW, Margolis B, et al.Comparative effectiveness research using the electronic medical record: an emerging area of investigation in pediatric primary care. J Pediatr. 2012;160(5):719-724.

Herman-Giddens ME, Steffes J, Harris D, Slora E, Hussey M, Dowshen S, Wasserman R, Serwint JR, Smitherman L, Reiter EO. Secondary sexual characteristics in boys: data from the Pediatric Research in Office Settings Network. Pediatrics. 2012; 130(5): e1058-e1068.

Nabi-Burza E, Regan S, Dempsey J, et al. Parents Smoking In Their Cars With Children. Pediatrics. 2012; 130(6): e1471-e1478.

Resnicow K, McMaster F, Woolford S, et al. Study design and baseline description of the BMI2 trial: reducing paediatric obesity in primary care practices. Pediatr Obes. 2012 Feb;7(1):3-15.

Winickoff JP, Hipple B, Drehmer J, et al. The Clinical Effort Against Secondhand Smoke Exposure (CEASE) Intervention: A Decade of Lessons Learned. Journal of Clinical Outcomes Management. 2012; 19(9): 414-419.

Ip EH, Wasserman R, Barkin S. Comparison of intraclass correlation coefficient estimates and standard errors between using cross-sectional and reapeated measurement data: the Safety Check cluster randomized trial. Contemp Clin Trials. 2011;32(2):225-232.

Sege R, Flaherty E, Jones R, et al. To report or not to report: examination of the initial primary care management of suspicious childhood injuries. Acad Pediatr. 2011;11(6):460-466.

Slora EJ, Bocian AB, Finch SA, Wasserman RC. Pediatric Research in Office Settings at 25: a quarter century of network research toward the betterment of children's health.

Wasserman R, Bocian A, Harris D,Slora E. Limited capacity in US pediatric drug trials: qualitative analysis of expert interviews. Paediatr Drugs. 2011;13(2):119-124.

Wasserman R, Serwint JR, Kuppermann N, Srivastava R, Dreyer B. The APA and the rise of pediatric generalist network research. Acad Pediatr. 2011;11(3):195-204.

Wasserman RC. Electronic medical records (EMRs), epidemiology, and epistemology: reflections on EMRs and future pediatric clinical research. Acad Pediatr. 2011;(4):280-287.

Slora EJ, Harris DL, Bocian AB, Wasserman RC. Pediatric clinical research networks: current status, common challenges, and potential solutions. Pediatrics. 2010;26(4):740-745.

Slora EJ, Wasserman RC. Pediatric Research in Office Settings (PROS): a research network to enhance practice and improve child health. Pediatr Ann. 2010;39(6):352-361.

Finch SA, Barkin SL, Wasserman RC, Dhepyasuwan N, Slora EJ, Sege RD. Effects of local institutional review board review on participationin national practice-based research network studies. Arch Pediatr Adolesc Med. 2009;163(12):1130-1134.

Slora EJ, Bocian AB, Herman-Giddens ME, et al. Assessing inter-rater reliability (IRR) of Tanner staging and orchidometer use with boys: a study from PROS. J Pediatr Endocrinol Metab. 2009;22(4):291-299.


Primary Care, Clinical Practice, Medical Home, Well-Child Pediatric Care

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