Funded Projects

Pediatric Emergency Care Applied Research Network (PECARN)

Project Website
Principal Investigator: Eileen Klein
Project Number: U03MC33156
Grantee: Seattle Children's Hospital
Department/Center: Pediatrics
Project Date: 9/30/2001

Age

Perinatal/Infancy (0-12 months)
Toddlerhood (13-35 months)
Early Childhood (3-5 years)
Middle Childhood (6-11 years)
Adolescence (12-18 years)

Abstract

The PECARN was created by the Maternal and Child Health Bureau through a partnership between the Emergency Medical Services for Children (EMSC) Program and the MCH Research Program. The goal of this network is to conduct high priority, meaningful and rigorous multi-institutional research into the prevention and management of acute illnesses and injuries in children and youth across the continuum of emergency medicine health care. PECARN, comprised of four regional multi-institutional nodes (University of California, Davis; University of Michigan; Children's National Medical Center; and Columbia University) and a central data management and coordinating center (University of Utah), is the first and only federally-funded national pediatric emergency medicine research network. Each node works collaboratively with the others and with MCHB to initiate, implement, and administer network research. The four Regional Node Centers (RNCs) and their 21 Hospital Emergency Department Affiliates (HEDAs) in the PECARN network serve approximately 800,000 acutely ill and injured children every year. PECARN provides the leadership and infrastructure to conduct multi-center research studies, support research collaboration among EMSC investigators, and promote informational EMSC exchanges between EMSC investigators and providers. Principal Investigators: Nathan Kuppermann, M.D., M.P.H., University of California, Davis; Ronald F. Maio, D.O., M.S., University of Michigan; Jim Chamberlain, M.D., Children's National Medical Center; Peter Dayan, M.D., M.Sc., Columbia University; J. Michael Dean, M.D., M.B.A., University of Utah. Period of Support: 09/30/2001 - 08/31/2008 (4 Regional Nodes) 09/01/2002 - 08/31/2009 (Central Data Center)

Publications

Listed is descending order by year published.

Badawy MK, Dayan PS, Tunik MG, et al. Pediatric Emergency Care Applied Research Network (PECARN). Prevalence of Brain Injuries and Recurrence of Seizures in Children With Posttraumatic Seizures. Acad Emerg Med. 2017 May;24(5):595-605.

Garro A, Chodobski A, Szmydynger-Chodobska J, et al. Pediatric Emergency Care Applied Research Network (PECARN). Circulating matrix metalloproteinases in children with diabetic ketoacidosis. Pediatr Diabetes. 2017 Mar;18(2):95-102.

Ahmad F, Schwartz H, Browne L, Claxton SL, Wallendorf M, Lerner EB, Kuppermann N, Leonard J. Methods for Collecting Paired Observations from Emergency Medical Services and Emergency Department Providers for Pediatric Cervical Spine Injury Risk Factor. Acad Emerg Med 2017;24:432-41.

Blumberg SM, Mahajan PV, OʼConnell KJ, et al. Pediatric Emergency Care Applied Research Network. Radiologic safety events within a pediatric emergency medicine network. Pediatric Emerg Care. 2017 Feb; 33(2): 92-6.

Carter PM, Cook LJ, Macy ML, et al. The Pediatric Emergency Care Applied Research Network (PECARN). Individual and Neighborhood Characteristics of Children Seeking Emergency Department Care for Firearm Injuries Within the PECARN Network. Acad Emerg Med. 2017 Jul;24(7):803-13.

Dayal P, Horeczko T, Wraa C, Karsteadt L, Chapman W, Bruhnke L, Litman R, Ruttan T, Kuppermann N, Marcin J. Emergency Medical Services Utilization by Children. Pediatr Emerg Care. 2017 Apr 11. [Epub ahead of print]

Dayan PS, Ballard DW, Tham E, et al. Pediatric Emergency Care Applied Research Network (PECARN); Clinical Research on Emergency Services and Treatment (CREST) Network; Partners Healthcare; Traumatic Brain Injury-Knowledge Translation Study Group. Use of Traumatic Brain Injury Prediction Rules With Clinical Decision Support. Pediatrics. 2017 Apr;139(4).

Holmes JF, Kelley KM, Wootton-Gorges SL, Utter GH, Abramson LP, Rose JS, Tancredi DJ, Kuppermann N. Effect of Abdominal Ultrasound on Clinical Care, Outcomes, and Resource Use Among Children With Blunt Torso Trauma: A Randomized Clinical Trial. JAMA. 2017 Jun 13;317(22):2290-2296

Nigrovic LE, Mahajan PV, Blumberg SM, Browne LR, Linakis JG, Ruddy RM, Bennett JE, Rogers AJ, Tzimenatos L, Powell EC, Alpern ER, Casper TC, Ramilo O, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants. Pediatrics. 2017 Jul;140(1).

Stanley RM, Johnson MD, Vance C, et al. Pediatric Emergency Care Applied Research Network (PECARN). Challenges enrolling children into traumatic brain injury trials: An observational study. Acad Emerg Med. 2017 Jan 24(1):31-39.

Atabaki SM, Hoyle JD Jr, Schunk JE, et al. Comparison of prediction rules and clinician suspicion for identifying children with clinically important brain injuries after blunt head trauma. Acad Emerg Med. 2016 May;23(5):566-75.

Grundmeier RW, Masino AJ, Casper TC, et al. Pediatric Emergency Care Applied Research Network. Identification of Long Bone Fractures in Radiology Reports Using Natural Language Processing to support Healthcare Quality Improvement. Appl Clin Inform. 2016 Nov 9;7(4):1051-1068.

Moler FW, Hutchison JS, Nadkarni VM, et al. Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial Investigators. Targeted temperature management after pediatric cardiac arrest due to drowning: Outcomes and complications. Pediatr Crit Care Med. 2016 Aug;17(8):712-20.

Silverstein FS, Slomine BS, Christensen J, et al. Functional Outcome Trajectories After Out-of Hospital Pediatric Cardiac Arrest. Crit Care Med. 2016 Dec;44(12):e1165-e1174.

Zonfrillo MR, Macy ML, Cook LJ, et al. Pediatric Emergency Care Applied Research Network (PECARN). Anticipated resource utilization for injury versus non-injury pediatric visits to emergency departments. Inj Epidemiol. 2016 Dec;3(1):12.

Babcock L, Olsen CS, Jaffe DM, et al. Cervical Spine Study Group for the Pediatric Emergency Care Applied Research Network (PECARN). Cervical spine injuries in children associated with sports and recreational activities. Pediatr Emerg Care. 2016 Sep 30. [epub ahead of print].

Borgialli DA, Mahajan P, Hoyle JD Jr, et al. Pediatric Emergency Care Applied Research Network (PECARN). Performance of the pediatric Glasgow Coma Scale score in the evaluation of children with blunt head trauma. Acad Emerg Med. 2016 Aug;23(8):878-84.

Browning B, Page KE, Kuhn RL, et al. Nurses' attitudes toward clinical research: Experience of the Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials. Pediatr Crit Care Med. 2016 Mar;17(3):e121-9.

Mahajan P, Kuppermann N, Mejias A, et al. Pediatric Emergency Care Applied Research Network (PECARN). Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. JAMA. 2016 Aug 23-30;316(8):846-57.

Meert KL, Slomine BS, Christensen JR, et al. Therapeutic Hypothermia after Pediatric Cardiac Arrest Trial Investigators. Family burden after out-of-hospital cardiac arrest in children. Pediatr Crit Care Med. 2016 Jun;17(6):498-507.

Meert KL, Telford R, Holubkov R, et al. Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med. 2016 Dec 17(12):e543-e550.

Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW; THAPCA Trial Investigators. Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events. Resuscitation. 2016 Dec 11;109:40-48.

Natale JE, Joseph JG, Rogers AJ, et al. Relationship of physician-identified patient race and ethnicity to use of computed tomography in pediatric blunt torso trauma. Acad Emerg Med. 2016 May;23(5):584-90.

Nimmer M, Czachor J, Turner L, et al. Sickle cell working group of the Pediatric Emergency Care Applied Research Network (PECARN). The benefits and challenges of preconsent in a multisite, pediatric sickle cell intervention trial. Pediatr Blood Cancer. 2016 Sep;63(9):1649-52.

Slomine B, Silverstein FS, Christensen JR, et al. THAPCA Trial Group. Neurobehavioral outcomes in children after out-of-hospital cardiac arrest. Pediatrics. 2016 Apr;137(4).

Spirito A, Bromberg JR, Casper TC, et al. Pediatric Emergency Care Applied Research Network. Reliability and Validity of a Two-Question Alcohol Screen in the Pediatric Emergency Department. Pediatrics. 2016 Dec;138(6).

Tham E, Swietlik M, Deakyne S, et al. Pediatric Emergency Care Applied Research Network (PECARN). Clinical Decision Support for a Multicenter Trial of Pediatric Head Trauma: Development, Implementation, and Lessons Learned. Appl Clin Inform. 2016 Jun 15;7(2):534-42.

Tunik MG, Powell EC, Mahajan P, et al. Pediatric Emergency Care Applied Research Network (PECARN). Clinical Presentations and Outcomes of Children With Basilar Skull Fractures After Blunt Head Trauma. Ann Emerg Med. 2016 Oct;68(4):431-40.e1.

Ellison AM, Quayle KS, Bonsu B, Garcia M, Blumberg S, Rogers A, Wootton-Gorges SL, Kerrey BT, Cook LJ, Cooper A, Kuppermann N, Holmes JF; Pediatric Emergency Care Applied Research Network (PECARN). Use of oral contrast for abdominal computed tomography in children with blunt torso trauma. Ann Emerg Med. 2015 Aug; 66(2):107-114.e4.

Holubkov R, Clark AE, Moler FW, et al. Efficacy outcome selection in the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med. 2015 Jan;16(1):1-10.

Lichenstein R, Monroe D, Quayle KS, et al. Pediatric Emergency Care Applied Research Network (PECARN). Television-related head injuries in children: A secondary analysis of a large cohort study of head-injured children in the Pediatric Emergency Care Applied Research Network. Pediatr Emerg Care. 2015 Nov 6. [Epub ahead of print].

82. Leonard JC, Jaffe DM, Olsen CS, Kuppermann N. Age-related differences in factors associated with cervical spine injuries in children. Acad Emerg Med. 2015 Apr; 22(4): 441-6.

Brousseau DC, Scott JP, Badaki-Makun O, et al. Pediatric Emergency Care Applied Research Network (PECARN). A multi-center randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children. Blood. 2015 Oct 1; 126(14): 1651-7.

Dayan PS, Holmes JF, Hoyle J Jr, et al. Pediatric Emergency care Applied Research Network (PECARN). Headache in traumatic brain injuries from blunt head trauma. Pediatrics. 2015 Mar;135(3):504-12.

Deakyne SJ, Bajaj L, Hoffman J, et al. Pediatric Emergency Care Applied Research Network (PECARN). Development, evaluation and implementation of chief complaint groupings to activate data collection: A multi-center study of clinical decision support for children with head trauma. Appl Clin Inform. 2015 Aug 19;6(3):521-35;eCollection 2015.

Glass T, Ruddy RM, Alpern ER, et al. Pediatric Emergency Care Applied Research Network (PECARN). Traumatic brain injuries and computed tomography use in pediatric sports participants. Am J Emerg Med. 2015 Oct;33(10):1458-64.

Holsti M, Zemek R, Baren J, et al. Variation of community consultation and public disclosure for a pediatric multi-centered "Exception from Informed Consent" trial. Clin Trials. 2015 Feb; 12(1):67-76.

Kwok MY, Yen K, Atabaki S, et al. Sensitivity of plain pelvis radiography in children with blunt torso trauma. Ann Emerg Med. 2015 Jan;65(1):63-71.e1.

Lichenstein R, O'Connell K, Funai T, Blumberg S, Shaw K, Ruddy R, Mahajan PV, Chamberlain JM. Laboratory errors in a pediatric emergency department network: An analysis of incident reports. Pediatr Emerg Care. 2015 Apr 1 [Epub ahead of print].

lsen CS, Kuppermann N, Jaffe DM, et al. Pediatric Emergency Care Applied Research Network (PECARN) Cervical Spine Injury Study Group. Interobserver agreement in retrospective chart reviews for factors associated with cervical spine injuries in children. Acad Emerg Med. 2015 Apr; 22(4):487-91.

Macy ML, Zonfrillo MR, Cook LJ, et al. Pediatric Emergency Care Applied Research Network. Patient-and community-level sociodemographic characteristics associated with emergency department visits for childhood injury. J Pediatr. 2015 Sep; 167(3):711-8.e1-4.

Mahajan P, Kuppermann N, Suarez N, et al. Febrile Infant Working Group for the Pediatric Emergency Care Applied Research Network (PECARN). RNA transcriptional biosignature analysis for identifying febrile infants with serious bacterial infections in the emergency department: a feasibility study. Pediatr Emerg Care. 2015 Jan;31(1):1-5.

Mahajan P, Kuppermann N, Tunik M, et al. Intra-abdominal Injury Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). Comparison of clinician suspicion versus a clinical prediction rule in identifying children at risk for intra-abdominal injuries after blunt torso trauma. Acad Emerg Med. 2015 Sep;22(9):1034-41.

Moler FW, Silverstein FS, Holubkov R, et al. THAPCA Trial Investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015 May 14;372(20):1898-908.

Ruddy RM, Chamberlain JM, Mahajan PV, et al. Pediatric Emergency Care Applied Research Network. Near misses and unsafe conditions reported in a pediatric emergency research network. BMJ Open. 2015 Sep 2;5(9):e007541.

Wisner DH, Kuppermann N, Cooper A, et al. Management of children with solid organ injuries after blunt torso trauma. J Trauma Acute Care Surg. 2015 Aug;79(2):206-14; quiz 332.

Alpern ER, Clark AE, Alessandrini EA, et al. Pediatric Emergency Care Applied Research Network (PECARN). Recurrent and high-frequency use of the emergency department by pediatric patients. Acad Emerg Med. 2014 Apr;21(4):365-73.

Adelgais KM, Kuppermann N, Kooistra J, et al. Intra-Abdominal Injury Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). Accuracy of the abdominal examination for identifying children with blunt intra-abdominal injuries. J Pediatr. 2014 Dec;165(6):1230-5.e5

Anders JF, Adelgais K, Hoyle JD Jr, Olsen C, Jaffe DM, Leonard JC, Pediatric Emergency Care Applied Research Network (PECARN). Comparison of outcomes for children with cervical spine injury based on destination hospital from scene of injury. Acad Emerg Med. 2014 Jan;21(1):55-64.

Badaki-Makun O, Scott JP, Panepinto JA, Casper TC, Hillery CA, Dean JM, Brousseau DC, Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group. Intravenous magnesium for pediatric sickle cell vaso-occlusive crisis: methodological issues of randomized controlled trial. Pediatric Blood and Cancer. 2014 Jun;61(6):1049-1054

Borgialli DA, Ellison AM, Ehrlich P, et al. Pediatric Emergency Care Applied Research Network (PECARN). Association between the seat belt sign and intra-abdominal injuries in children with blunt torso trauma in motor vehicle collisions. Acad Emerg Med. 2014 Nov;21(11):1240-8.

Chamberlain JM, Okada P, Holsti M, et al. Pediatric Emergency Care Applied Research Network (PECARN). Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. JAMA. 2014 Apr 23-30;311(16):1652-60.

Dayan PS, Holmes JF, Atabaki S, Hoyle J Jr, Tunik MG, Lichenstein R, Alpern E, Miskin M, Kuppermann N, Traumatic Brain Injury Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). Association of traumatic brain injuries with vomiting in children with blunt head trauma. Ann Emerg Med. 2014 Jun;63(6):657-665.

Hoyle JD Jr, Callahan JM, Badawy M, Powell E, Jacobs E, Gerardi M, Melville K, Miskin M, Atabaki SM, Dayan P, Holmes JF, Kuppermann N, Traumatic Brain Injury Study Group for the Pediatric Emergency Care Applied Research Network (PECARN). Pharmacological sedation for cranial computed tomography in children after minor blunt head trauma. Pediatr Emerg Care. 2014 Jan;30(1):1-7.

Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P, Lichenstein R, Lillis KA, Tunik MG, Jacobs ES, Callahan JM, Gorelick MH, Glass TF, Lee LK, Bachman MC, Cooper A, Powell EC, Gerardi MJ, Melville KA, Muizelaar JP, Wisner DH, Zuspan SJ, Dean JM, Wootton-Gorges SL, Pediatric Emergency Care Applied Research Network (PECARN). Identification of childen at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Erratum in Lancet 2014. Jan 25;383(9914):308.

Lee LK, Monroe D, Bachman MC, et al. Traumatic Brain Injury (TBI) Working Group of Pediatric Emergency Care Applied Research Network (PECARN). Isolated loss of consciousness in children with minor blunt head trauma. JAMA Pediatr. 2014 Sep;168(9):837-43.

Lee LK, Rogers AJ, Ehrlich PF, et al. Pediatric Emergency Care Applied Research Network (PECARN). Occult pneumothoraces in children with blunt torso trauma. Acad Emerg Med. 2014 Apr;21(4):440-8.

Leonard JR, Jaffe DM, Kuppermann N, et al. Pediatric Emergency Care Applied Research Network (PECARN). Cervical spine injury patterns in children. Pediatrics. 2014 May;133(5):e1179-88.

Lerner EB, Dayan PS, Brown K, Fuchs S, Leonard J, Borgialli D, Babcock L, Hoyle JD Jr, Kwok M, Lillis K, Nigrovic LE, Mahajan P, Rogers A, Schwartz H, Soprano J, Tsarouhas N, Turnipseed S, Funai T, Foltin G, Pediatric Emergency Care Applied Research Network (PECARN). Characteristics of the pediatric patients treated by the Pediatric Emergency Care Applied Research Networks affiliated EMS agencies. Prehos Emerg Care. 2014 Jan-Mar;18(1):52-59.

Mahajan P, Grzybowski M, Chen X, Kannikeswaran N, Stanley R, Singal B, Hoyle J Jr, Borgialli D, Duffy E, Kuppermann N. Procalcitonin as a marker of serious bacterial infections in febrile children younger than 3 years old. Acad Emerg Med. 2014 Feb;21(2):171-179.

Menaker J, Blumberg S, Wisner DH, et al. Intra-abdominal Injury Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). Use of the focused assessment with sonography for trauma (FAST) examination and its impact on abdominal computed tomography use in hemodynamically stable children with blunt torso trauma. J Trauma Acute Care Surg. 2014 Sep;77(3):427-32

Stanley RM, Hoyle JD Jr, Dayan PS, et al. Pediatric Emergency Care Applied Research Network (PECARN). Emergency department practice variation in computed tomography use for children with minor blunt head trauma. J Pediatr. 2014 Dec;165(6):1201-6.e2

Topjian AA, French B, Sutton RM, et al. Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Crit Care Med. 2014 Jun;42(6): 1518-23.

Bennett KS, Clark AE, Meert L, Topjian AA, Schleien CL, Shaffner DH, Dean JM, Moler FW, Pediatric Emergency Care Applied Research Network. Early oxygenation and ventilation measurements after pediatric cardiac arrest: lack of association with outcome. Crit Care Med. 2013 Jun;41(6):1534-1542.

Chamberlain JM, Shaw KN, Lillis KA, Mahajan PV, Ruddy RM, Lichenstein R, Olsen CS, Dean JM, Pediatric Emergency Care Applied Research Network. Creating an infrastructure for safety event reporting and analysis in a multicenter pediatric emergency department network. Pediatr Emerg Care. 2013 Feb;29(2):125-130.

Dalziel SR, Thompson JM, Macias CG, Fernandes RM, Johnson DW, Waisman Y, Cheng N, Acworth J, Chamberlain JM, Osmond MH, Plint A, Valerio P, Black KJ, Fitzpatrick E, Newton AS, Kuppermann N, Klassen TP, Pediatric Emergency Research Networks H1N1 Working Group. Predictors of severe H1N1 infection in children presenting within Pediatric Emergency Research Networks (PERN): a retrospective case-control study. BMJ. 2013 Aug;12(347):f4836.

Garcia M, Taylor G, Babcock L, Dillman JR, Iqbal V, Quijano CV, Wootton-Gorges SL, Adelgais K, Anupindi SA, Sonavane S, Joshi A, Veeramani M, Atabaki SM, Monroe DJ, Blumberg SJ, Ruzal-Shapiro C, Cook LJ, Dayan PS, Pediatric Emergency Care Applied Research Network (PECARN). Computed tomography with intravenous contrast alone: the role of intra-abdominal fat on the ability to visualize the normal appendix in children. Acad Emerg Med. 2013 Aug;20(8):795-800.

Glaser NS, Ghetti S, Casper TC, Dean JM, Kuppermann N, Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Pediatric diabetic ketoacidosis, fluid therapy and cerebral injury: the design of a factorial randomized controlled trial. Pediatr Diabetes. 2013 Sep;14(6): 435-446.

Holmes JF, Lillis K, Monroe D, Borgialli D, Kerrey BT, Mahajan P, Adelgais K, Ellison AM, Yen K, Atabaki S, Menaker J, Bonsu B, Quayle KS, Garcia M, Rogers A, Blumberg S, Lee L, Tunik M, Kooistra J, Kwok M, Cook LJ, Dean JM, Sokolove PE, Wisner DH, Ehrlich P, Cooper A, Dayan PS, Wootton-Gorges S, Kuppermann N, Pediatric Emergency Care Applied Research Network (PECARN). Identifying children at very low risk of clinically important blunt abdominal injuries. Ann Emerg Med. 2013 Aug; 62(2):107-116.e2

Kerrey BT, Rogers AJ, Lee LK, Adelgais K, Tunik M, Blumberg SM, Quayle KS, Sokolove PE, Wisner DH, Miskin ML, Kuppermann N, Holmes JF, Pediatric Emergency Care Applied Research Network. A multicenter study of the risk of intra-abdominal injury in children after normal abdominal computed tomography scan results in the emergency department. Ann Emerg Med. 2013 Oct;62(4):319-326.

Kim EG, Brown KM, Leonard JC, Jaffe DM, Olsen CS, Kuppermann N, C-Spine Study Group for the Pediatric Emergency Care Applied Research Network (PECARN). Variability of prehospital spinal immobilization in children at risk for cervical spine injury. Pediatr Emerg Care. 2013 Apr;29(4):413-418.

Mahajan P, Jaffe DM, Olsen CS, Leonard JR, Nigrovic LE, Rogers AJ, Kuppermann N, Leonard JC. Spinal cord injury without radiologic abnormality in children with magnetic resonance imaging. J Trauma Acute Care Surg. 2013 Nov;75(5):843-847.

Mahajan P, Ramilo O, Kupperman N. The future possibilites of diagnostic testing for the evaluation of febrile infants. JAMA Pediatri. 2013 Oct;167(10):888-898.

Moler FW, Silverstein FS, Meert KL, Clark AE, Holubkov R, Browning B, Slomine BS, Christensen JR, Dean JM. Rationale, timeline, study design and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med. 2013 Sep;14(7): e304-e315.

Nigrovic LE, Lillis K, Atabaki SM, Dayan PS, Hoyle J, Tunik MG, Jacobs ES, Monroe D, Wootton-Gorges SW, Miskin M, Holmes JF, Kuppermann N, Traumatic Brain Injury (TBI) Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). The prevalence of traumatic brain injuries after minor blunt head trauma in children with ventricular shunts. Ann Emerg Med. 2013 Apr;61(4):389-393.

Pemberton VL, Browning B, Webster A, Dean JM, Moler FW. Therapeutic hypothermia after pediatric cardiac arrest trials: the vanguard phase experience and implications for other trials. Pediatr Crit Care Med. 2013 Jan;14(1): 19-26.

Rogers AJ, Maher CO, Schunk JE, Quayle K, Jacobs E, Lichenstein R, Powell E, Miskin M, Dayan P, Holmes JF, Kuppermann N, Pediatric Emergency Care Applied Research Network. Incidental findings in children with blunt head trauma evaluated with cranial CT scans. Pediatrics. 2013 Aug;132(2):356-363.

Shaw KN, Lillis KA, Ruddy RM, Mahajan PV, Lichenstein R, Olsen CS, Chamberlain JM, Pediatric Emergency Care Applied Research Network. Reported medication events in a paediatric emergency research network: sharing to improve patient safety. Emerg Med J. 2013 Oct; 30(10):815-819.

Sheehan B, Nigrovic LE, Dayan PS, Kuppermann N, Ballard DW, Alessandrini E, Bajaj L, Goldberg H, Hoffman J, Offerman SR, Mark DG, Swietlik M, Tham E, Tzimenatos L, Vinson DR, Jones GS, Bakken S, Pediatric Emergency Care Applied Research Network (PECARN). Informing the design of clinical decision support services for evaluation of children with minor blunt head trauma in the emergency department: a sociotechnical analysis. J Biomed Inform. 2013 Oct;46(5):905-913.

Topjian AA, Clark AE, Casper TC, Berger JT, Schleien CL, Dean JM, Moler FW, Pediatric Emergency Care Applied Research Network. Early lactate elevations following resuscitation from pediatric cardiac arrest are associated with increased mortality. Pediatr Crit Care Med. 2013 Oct;14(8):e380-e387.

Yen K, Kuppermann N, Lillis K, Monroe D, Borgialli D, Kerrey BT, Sokolove PE, Ellison AM, Cook LJ, Holmes JF. Interobserver agreement in the clinical assessment of children with blunt abdominal trauma. Acad Emerg Med. 2013 May;20(5):426-432.

Alessandrini EA, Alpern ER, Chamberlain JM, Shea JA, Holubkov R, Gorelick MH, Pediatric Emergency Care Applied Research Network. Developing a diagnosis-based severity classification system for use in emergency medical services for children. Acad Emerg Med. 2012 Jan;19(1):70-78.

Chamberlain JM, Capparelli EV, Brown KM, Vance CW, Lillis K, Mahajan P, Lichenstein R, Stanley RM, Davis CO, Gordon S, Baren JM, van den Anker JN. Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. J Pediatr. 2012 April;160(4)667-672.e2.

Corneli HM, Zorc JJ, Holubkov R, Bregstein JS, Brown KM, Mahajan P, Kuppermann N, Bronchiolitis Study Group for the Pediatric Emergency Care Applied Research Network. Bronchiolitis: clinical characteristics associated with hospitalization and length of stay. Pediatr Emerg Care. 2012 Feb; 28(2):99-103.

Leonard JC, Scharff DP, Koors V, Lerner EB, Adelgais KM, Anders J, Brown K, Babcock L, Lichenstein R, Lillis KA, Jaffe DM. A qualitative assessment of factors that influence emergency medical services partnerships in prehospital research. Acad Emerg Med. 2012 Feb;19(2):161-173.

Lichenstein R, Glass TF, Quayle KS, Wootton-Gorges SL, Wisner DH, Miskin M, Muizelaar JP, Badawy M, Atabaki S, Holmes JF, Kuppermann N, Traumatic Brain Injury Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). Presentations and outcomes of children with intraventricular hemorrhages after blunt head trauma. Arch Pediatr Adolesc Med. 2012 Aug; 166(8):725-731.

Natale JE, Joseph JG, Rogers AJ, Mahajan P, Cooper A, Wisner DH, Miskin ML, Hoyle JD Jr, Atabaki SM, Dayan PS, Holmes JF, Kuppermann N, PECARN (Pediatric Emergency Care Applied Research Network). Cranial computed tomography use among children with minor blunt head trauma: association with race/ethnicity. Arch Pediatr Adolesc Med. 2012 Aug;166(8):732-737.

Nigrovic LE, Rogers AJ, Adelgais KM, Olson CS, Leonard JR, Jaffe DM, Leonard JC, Pediatric Emergency Care Applied Research Network (PECARN) Cervical Spine Study Group. Utility of plain radiographs in detecting traumatic injuries of the cervical spine in children. Pediatr Emerg Care. 2012 May;28(5):426-432.

Timm NL, McAneney C, Alpern E, Macy M, Ruddy R. Is pediatric emergency department utilization by pregnant adolescents on the rise? Pediatr Emerg Care. 2012 Apr;28(4):307-309.

Alessandrini E, Varadarajan K, Alpern ER, Gorelick MH, Shaw KN, Ruddy RM, Chamberlain JM, Pediatric Emergency Care Applied Research Network. Emergency department quality : an analysis of existing pediatric measures. Acad Emerg Med. 2011 May;18(5):519-526.

Dayan PS, Lillis K, Bennett J, Conners G, Bailey P, Callahan J, Akman C, Feldstein N, Hauser WA, Kuppermann N, Pediatric Emergency Department Northeast Team of the PECARN. Interobserver agreement in the assessment of clinical findings in children with first unprovoked seizures. Pediatrics. 2011 May;127(5):e 1266-1271.

Holmes JF, Borgialli DA, Nadel FM, Quayle KS, Schamban N, Cooper A, Schunk JE, Miskin ML, Atabaki SM, Hoyle JD, Dayan PS, Kuppermann N, TBI Study Group for the Pediatric Emergency Care Applied Research Network. Do children with blunt head trauma and normal cranial computed tomography scan results require hospitalization for neurologic observation? Ann Emerg Med. 2011 Oct;58(4):315-322.

Lee LK, Dayan PS, Gerardi MJ, Borgialli DA, Badawy MK, Callahan JM, Lillis KA, Stanley RM, Gorelick MH, Dong L, Zuspan SJ, Holmes JF, Kuppermann N, Traumatic Brain Injury Working Group for the Pediatric Emergency Care Applied Research Network (PECARN). Intracranial hemorrhage after blunt head trauma in children with bleeding disorders. J Pediatr. 2011 Jun;158(6):1003-1008.e1-2.

Leonard JC, Kuppermann N, Olsen C, Babcock-Cimpello L, Brown KM, Mahajan P, Adelgais K, Anders J, Borgialli D, Donoghue A, Hoyle JD Jr, Kim E, Leonard JR, Lillis KA, Nigrovic LE, Powell EC, Rebella G, Reeves SD, Rogers AJ, Stankovic C, Teshome G, Jaffe DM, Pediatric Emergency Care Applied Research Network. Factors associated with cervical spine injury in children after blunt trauma. Ann Emerg Med. 2011 Aug; 58(2):145-155.

Moler FW, Donaldson AE, Meert K, Brilli RJ, Nadkarni V, Shaffner DH, Schleien CL, Clark RS, Dalton HJ, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Pineda J, Hernan L, Dean JM, Pediatric Emergency Care Applied Research Network (PECARN). Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med. 2011 Jan;39(1):141-149.

Nigrovic LE, Lee LK, Hoyle J, Stanley RM, Gorelick MH, Miskin M, Atabaki SM, Dayan PS, Holmes JF, Kuppermann N, Traumatic Brain Injury (TBI) Working Group of Pediatric Emergency Care Applied Research Network (PECARN). Prevalence of clinically important traumatic brain injuries in children with minor blunt head trauma and isolated sever injury mechanisms. Arch Pediatr Adolesc Med. 2012 Apr;166(4):356-361

Nigrovic LE, Schunk JE, Foerster A, Cooper A, Miskin M, Atabaki SM, Hoyle J, Dayan PS, Holmes JF, Kuppermann N, Traumatic Brain Injury Group for the Pediatric Emergency Care Applied Research Network. The effect of observation on cranial computed tomography utilization for children after blunt head trauma. Pediatrics. 2011 Jun;127(6):1067-1073.

Alessandrini EA, Alpern ER, Chamberlain JM, Shea JA, Gorelick MH. A new diagnosis grouping system for child emergency department visits. Acad Emerg Med. 2010 Feb;17(2):204-213.

Foltin GL, Dayan P, Tunik M, Marr M, Leonard J, Brown K, et al. Priorities for pediatric prehospital research. Pediatr Emerg Care. 2010 Oct;26(10):773-777.

Foltin GL, Dayan P, Tunik M, Marr M, Leonard J, Brown K, Hoyle J Jr, Lerner EB, Prehospital Working Group of the Pediatric Emergency Care Applied Research Network. Priorities for pediatric prehospital research. Pediatr Emerg Care. 2010 Oct;26(10)773-777.

Klassen TP, Acworth J, Bialy L, Black K, Chamberlain JM, Cheng N, et al. Pediatric emergency research networks: a global initiative in pediatric emergency medicine. Pediatr Emerg Care. 2010 Aug;26(8):541-543.

Stanley R, Lillis K, Zuspan SJ, Lichenstein R, Ruddy RM, Gerardi MJ, Dean JM, Pediatric Emergency Care Applied Research Network (PECARN). Development and implementation of a performance measure tool in an academic pediatric research network. Contemp Clin Trials. 2010 Sep;31(5):429-437.

Bhatt M, Kennedy RM, Osmond MH, Krauss B, McAllister JD, Ansermino JM, Evered LM, Roback MG, Consensus Panel on Sedation Research of Pediatric Emergency Research Canada (PERC), Pediatric Emergency Care Applied Research Network (PECARN). Consensus-based recommendationks for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children. Ann Emerg Med. 2009 Apr;53(4):426-435.

Chamberlain JM, Lillis K, Vance C, Brown KM, Fawumi O, Nichols S, Davis CO, Singh T, Baren JM, Pediatric Emergency Care Applied Research Network (PECARN). Perceived challenges to obtaining informed consent for a time-sensitive emergency department study of pediatric status epilepticus: results of two focus groups. Acad Emerg Med. 2009 Aug;16(8):763-770.

Grupp-Phelan J, Mahajan P, Foltin GL, Jacobs E, Tunik M, Sonnett M, Miller S, Dayan P, Pediatric Emergency Care Applied Research Network. Referral and resource utilization patterns for psychiatric related visits to pediatric emergency departments. Pediatr Emerg Care. 2009 Apr;25(4):217-220.

Holmes JF, Holubkov R, Kuppermann N, Pediatric Emergency Care Applied Research Network (PECARN). Guardian availability for children evaluated in the emergency department for blunt head trauma. Acad Emerg Med. 2009 Jan;16(1):15-20.

Mahajan P, Alpern ER, Grupp-Phelan J, Chamberlain J, Dong L, Holubkov R, Jacobs E, Stanley R, Tunik M, Sonnett M, Miller S, Foltin GL, Pediatric Emergency Care Applied Research Network (PECARN). Epidemiology of psychiatric-related visits to emergency departments in a multi-center collaborative research pediatric network. Pediatr Emerg Care. 2009 Nov;25(11):715-720.

Meert KL, Donaldson A, Nadkarni V, Tieves KS, Schleien CL, Brilli RJ, Clark RS, Shaffner DH, Levy F, Statler K, Dalton HJ, van der Jagt EW, Hackbarth R, Pretzlaff R, Hernan L, Dean JM, Moler FW, Pediatric Emergency Care Applied Research Network (PECARN). Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med. 2009 Sep;10(5):544-553.

Moler FW, Meert K, Donaldson AE, Nadkarni V, Brilli RJ, Dalton HJ, Clark RS, Shaffner DH, Schleien CL, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, vander Jagt EW, Levy F, Hernan L, Silverstein FS, Dean JM, Pediatric Emergency Care Applied Research Network (PECARN). In-hospital versus out-of-hospital pediatric cardiac arrest: A multicenter cohort study. Crit Care Med. 2009 Jul;37(7):2259-2267.

Shaw KN, Ruddy RM, Olsen CS, Lillis KA, Mahajan PV, Dean JM, Chamberlain JM, Pediatric Emergency Care Applied Research Network (PECARN). Pediatric patient safety in emergency departments: unit characteristics and staff perceptions. Pediatrics. 2009 Aug;124(2):485-493.

Gorelick MH, Atabacki SM, Hoyle JD, Dayan PS, Holmes JF, Holubkov R, Monroe D, Callahan JM, Kuppermann N, Pediatric Emergency Care Applied Research Network (PECARN). Interobserver agreement in assessment of clinical variables in children with blunt head trauma. Acad Emerg Med. 2008 Sep;15(9):812-818.

Chamberlain JM, Singh T, Baren JM, Maio RF; Pediatric Emergency Care Applied Research Network. Food and Drug Administration public hearing on the conduct of emergency clinnical research: testimony of Pediatric Emergency Care Applied Research Network. Acad Emerg Med. 2007 Apr;14(4):e41-2.

Corneli HM, Zorc JJ, Mahajan P, Shaw KN, Holubkov R, Reeves SD et al; Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med. 2007 Jul 26;357(4):331-339.

Gorelick MH, Knight S, Alessandrini EA, Stanley RM, Chamberlain JM, Kuppermann N, Alpern ER; Pediatric Emergency Care Applied Research Network. Lack of agreement in pediatric emergency visit discharge diagnoses from administrative and clinical data sources. Acad Emerg Med. 2007 Jul;14(7):646-652. Epub 2007 Jun 6.

Stanley RM, Teach SJ, Mann NC, Alpern ER, Gerardi MJ, Mahajan PV, Chamberlain JM; Pediatric Emergency Care Applied Research Network. Variation in ancillary testing among pediatric asthma patients seen in emergency departments. Acad Emerg Med. 2007 Jun;14(6):532-538.

Alpern ER, Stanley RM, Gorelick MH, Donaldson A, Knight S, Teach SJ, et al; Pediatric Emergency Care Applied Research Network. Epidemiology of a pediatric emergency medicine research network: the PECARN Core Data Project. Pediatr Emerg Care. 2006 Oct;22(10):689-699.

Dayan P, Chamberlain J, Dean JM, Maio RF, Kupperman N. The pediatric emergency care applied research network: progress and update. Clin Pediatr Emerg Med. 2006 June;7(2):128-35.

Zuspan, SJ. The pediatric emergency care applied research network. J Emerg Nurs. 2006 Aug;32(4):299-303.

Boyd RC, Le HN, Somberg R. Review of screening instruments for postpartum depression. Arch Womens Ment Health. 2005 Sep;8(3):141-153.

Gorelick MH, Alpern ER, Singh T, Snowdon D, Holubkov R, Dean JM, et al; Pediatric Emergency Care Applied Research Network (PECARN). Availability of pediatric emergency visit data from existing data sources. Acad Emerg Med. 2005 Dec;12(12):1195-1200.

Pediatric Emergency Care Applied Research Network. The Pediatric Emergency Care Applied Research Network (PECARN): ratoinale, development, and first steps. Acad Emerg Med. 2003 Jun;10(6):661-668.

Pediatric Emergency Care Applied Research Network. The Pediatric Emergency Care Applied Research Network (PECARN): ratoinale, development, and first steps. Pediatr Emerg Care. 2003 Jun:19:185-193.

Date Last Reviewed:

December 2022

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