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Maternal and Child Health Pediatric Research Network Program. PROS (MCH PedsRN)

Project Website
Principal Investigator: Alexander Fiks
Project Number: U5DMC39344
Grantee: American Academy of Pediatrics
Department/Center: Department of Research/ Pediatric Research in Office Settings (PROS)
Project Date: 09/01/2020


  • Perinatal/Infancy (0-12 months)
  • Toddlerhood (13-35 months)
  • Early Childhood (3-5 years)
  • Middle Childhood (6-11 years)
  • Adolescence (12-18 years)

Targeted/Underserved Population

  • African American
  • Asian/Pacific Islander
  • Hispanic/Latino
  • Native American/Alaskan Native



For 34 years, the American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) national primary care practice-based research network (RN) has conducted groundbreaking stakeholder-informed research that: 1) builds the evidence-base for primary care; 2) informs clinical policy (including practice guidelines); and 3) provides new resources and tools for practices and families. Practice based research is needed to address the unmet needs of children across the life course, the changing epidemiology of pediatric disease, and the remaining gaps in the evidence base for primary care. The capacity for responsive practice-based research has heightened importance in a time of rapid change due to COVID-19.

Goals and Objectives:

PROS will 1) lead, promote, and coordinate national research to improve the physical health and well-being of children and adolescents; 2) maintain and augment a national RN infrastructure to support a portfolio of multi-site, interdisciplinary research, accelerate translation of research to policy and practice, and provide a mentoring environment for trainees; 3) advance health equity by conducting research that addresses the needs of underserved and safety net populations; and 4) conduct timely and innovative research in pediatric primary care that addresses HRSA priorities. PROPOSED ACTIVITIES AND TARGET POPULATION(S): PROS will conduct multiple primary care intervention trials of national scope that address the needs of children including the underserved; maintain and innovate the research network, building capacity for high impact implementation and dissemination of study findings; and help develop the next generation of leaders in practice-based research. Target populations include children from birth through adolescence, their families, pediatric clinicians, policymakers, and other stakeholders.


PROS will continue to link expert researchers with our network of primary care pediatric clinicians. PROS will cultivate connections between pediatric clinicians, researchers, parents, and stakeholders via in-person and virtual meetings. Dissemination and implementation of results will be maximized through linkage to AAP programs and communications. PRODUCTS: Products under this proposal include grant submissions, externally funded large studies of national scope, peer-reviewed publications and presentations, tools for clinicians and other pediatric professionals, and evidence to inform clinical policy.


Progress is monitored through the number and reach of products, tracking of evaluation measures, and regular reporting to MCHB.


Listed is descending order by year published.

Nabi-Burza E, Wasserman R, Drehmer J, et al. Spontaneous Smoking Cessation in Parents. Journal of Smoking Cessation, Vol. 2021, Article ID 5526715, 2021. doi/10.1155/2021/5526715

Szilagyi P, Humiston S, Stephens-Shields A, et al.  Effect of Training Pediatric Clinicians in Human Papillomavirus Communication Strategies on Human Papillomavirus Vaccination Rates: A Cluster Randomized Clinical Trial. JAMA Pediatr. 2021;175(9):901-910. doi:10.1001/jamapediatrics.2021.0766

Nekrasova E, Stockwell M, Localio R, et al. Vaccine hesitancy and influenza beliefs among parents of children requiring a second dose of influenza vaccine in a season: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) study. Human Vaccines & Immunotherapeutics, 2020, Feb 4:1-8.

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